Why the study?
Is left atrial appendage closure with the Amplatzer Cardiac Plug safe and effective for preventing thromboembolic events in high-risk patients with nonvalvular atrial fibrillation?
Is left atrial appendage closure with the Amplatzer Cardiac Plug safe and effective for preventing thromboembolic events in high-risk patients with nonvalvular atrial fibrillation?
In a small case series, left atrial appendage closure with the Amplatzer Cardiac Plug was safe and associated with no thromboembolic or bleeding events at 12 months in high-risk patients with nonvalvular atrial fibrillation.
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Supports safety of Amplatzer Cardiac Plug in high-risk nonvalvular AF; leaves open need for RCTs before practice change.
Costa et al. (2017) studied this question.
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