Feasibility of a registry-integrated eHealth program for managing fatigue and cognitive problems in multiple sclerosis

Objectives: Fatigue and cognitive impairment are common in people with multiple sclerosis (pwMS). This study evaluated the feasibility of a digital symptom management program integrated into the Finnish MS Registry targeting fatigue and cognitive symptoms. Materials and Methods: Forty pwMS with subjective fatigue and cognitive concerns enrolled in an eight-session eHealth program including symptom self-assessments, a mobile fatigue diary, individualized goal setting, and feedback from a neuropsychologist. Feasibility outcomes were completion rate, perceived usefulness, and technical functionality. Patient-reported outcome measures (PROMs) included the Goal Attainment Scale (GAS), Global Rating of Change (GRC), Fatigue Scale for Motor and Cognitive Functions, Multiple Sclerosis Neuropsychological Questionnaire, patient-reported Expanded Disability Status Scale, Visual Analogue Scales for neurological symptoms, and EQ-5D-5L. Results: Twenty-three participants (58%) completed the program with follow-up. The program was rated useful by 65% and technically appropriate by 70%. The mean GAS T-score was 50 both postintervention and at follow-up. Mean GRC scores indicated slightly positive change in managing fatigue (+1.4), cognitive symptoms (+1.3), and overall effects (+1.8). Other PROM changes were minimal. Conclusions: The registry-integrated eHealth program showed potential to support the management of fatigue and cognitive symptoms in pwMS. Further development and evaluation of digital symptom management tools are warranted.