Why the study?
Hypertension and diabetes cause CKD and diastolic left ventricular dysfunction, but whether combining urinary peptidomic profiling with home blood pressure telemonitoring improves risk factor management and prevention is unknown.
Does early communication of urinary peptidomic profiling (UPP) risk profile combined with home blood pressure telemonitoring reduce new-onset cardiovascular and renal outcomes in asymptomatic patients with multiple risk factors?
Population
1148 asymptomatic patients aged 55-75 years with ≥5 CKD- or DVD-related risk factors
Comparison
Early communication of UPP risk profile vs communication at trial closure, both with HTM
Design
Investigator-initiated randomized clinical trial with patient-centred design
Follow-up
5 years
Authors
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No practice change from protocol alone; leaves open whether UPP profiling plus telemonitoring prevents outcomes in high-risk patients.
Does early communication of urinary peptidomic profiling (UPP) risk profile combined with home blood pressure telemonitoring reduce new-onset cardiovascular and renal outcomes in asymptomatic patients with multiple risk factors?
The UPRIGHT-HTM trial protocol outlines a study to determine if early knowledge of urinary peptidomic profiling risk profiles combined with home blood pressure telemonitoring can prevent cardiovascular and renal outcomes in high-risk asymptomatic patients.
Thijs et al. (2021) studied this question.
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