What question did this study set out to answer?

To compare cardiovascular risk factor profiles, cardiac function, and cardiovascular disease outcomes between Black and non-Black African patients with chronic kidney disease.

February 19, 2021International Journal of NephrologyOpen Access

Cardiovascular Risk Factor Profiles and Disease in Black Compared to Other Africans with Chronic Kidney Disease

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Why the study?

The extent to which chronic kidney disease impacts cardiovascular disease in black Africans is uncertain.

Do cardiovascular risk factor profiles and disease burden differ between black and other African patients with chronic kidney disease?

Population

115 consecutive predialysis and dialysis CKD patients, including 46 black and 69 other African participants

Comparison

Black vs other African CKD patients

Design

Consecutive cohort study

Authors

HHHon‐Chun HsuUniversity of the Witwatersrand CRChanel RobinsonWestern Cape Department of Health AWAngela J. WoodiwissUniversity of the Witwatersrand

Discussion

Member takes

Implication

May support ethnicity-informed CV risk stratification in African CKD; leaves open generalizability and mechanisms in prospective cohorts.

Key Points

To compare cardiovascular risk factor profiles, cardiac function, and cardiovascular disease outcomes between Black and non-Black African patients with chronic kidney disease.
Assessed 115 consecutive predialysis (n = 67) and dialysis (n = 48) patients, comprising 46 Black and 69 non-Black participants (32 Asian, 28 White, 9 mixed race).
Evaluated cardiovascular risk profiles, aortic and cardiac function, carotid atherosclerosis extent, and cardiovascular event rates using multivariable regression and receiver operating characteristic models.
Black patients had significantly lower odds of carotid plaque (OR 0.38, 95% CI 0.16–0.91), and the Framingham score poorly discriminated plaque in Black (AUC 0.556, 95% CI 0.375–0.921) versus non-Black patients (AUC 0.818, 95% CI 0.714–0.921).
Predialysis Black patients had similar cardiovascular event rates compared to other Africans (OR 0.93, 95% CI 0.22–3.87) despite higher nontraditional risk factors and impaired arterial function.
Dialysis Black patients demonstrated increased ejection fraction (partial R = 0.356, p = 0.01), higher stroke volume (partial R = 0.315, p = 0.03), and significantly fewer cardiovascular events (OR 0.22, 95% CI 0.05–0.88).

Structured PICO

Do cardiovascular risk factor profiles and disease burden differ between black and other African patients with chronic kidney disease?

Population

115 consecutive predialysis (n=67) and dialysis (n=48) patients with chronic kidney disease, including 46 black and 69 other (32 Asian, 28 white, and 9 mixed race) African participants.

Intervention

Black African race/ethnicity

Comparator

Other African race/ethnicity (Asian, white, and mixed race)

Outcome

Cardiovascular risk factors, aortic and cardiac function, atherosclerosis extent (including carotid artery plaque), and cardiovascular event rates

Black African patients with CKD have less frequent carotid atherosclerosis and weaker associations between traditional risk factors and cardiovascular disease compared to other African CKD patients.

Cite This Study

Hsu et al. (2021) studied this question.

synapsesocial.com/papers/6a8216a0d96cdbb40a9cd1cf https://doi.org/10.1155/2021/8876363

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Cardiovascular Risk Factor Profiles and Disease in Black Compared to Other Africans with Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Cardiovascular Risk Factor Profiles and Disease in Black Compared to Other Africans with Chronic Kidney Disease

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider