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July 12, 2012Journal of VirologyOpen Access

Mutations That Hamper Dimerization of Foot-and-Mouth Disease Virus 3A Protein Are Detrimental for Infectivity

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Population

Foot-and-mouth disease virus 3A protein, transiently expressed 3A proteins, and synthetic peptides…

Comparison

Mutations in the 3A protein vs Wild-type FMDV 3A protein

Design

Preclinical

Authors

MGMónica González-MagaldiThe University of Texas at AustinRPRaúl PostigoConsejo Superior de Investigaciones CientíficasBTBeatriz G. de la TorreCollege of Medical Sciences

Discussion

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Implication

May inform FMDV antiviral design targeting 3A; leaves open validation in mammalian models before any clinical consideration.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) 3A protein, transiently expressed 3A proteins, and synthetic peptides reproducing the N terminus of 3A
I
Intervention
Mutations in the 3A protein (L38E, L41E, Q44R, Q44D)
C
Comparator
Wild-type FMDV 3A protein
O
Outcome
3A homodimerization and virus infectivity/replicationsurrogate

Preservation of the hydrophobic interface in FMDV 3A protein is essential for its homodimerization and virus replication.

Cite This Study

González-Magaldi et al. (2012) studied this question.

synapsesocial.com/papers/6a821785f10a9fcdd646bdfbhttps://doi.org/10.1128/jvi.00580-12
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Also Consider

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  1. 1Deletion or substitution of the aphthovirus 3′ NCR abrogates infectivity and virus replication2001 · 77 citations
  2. 2Infection with foot-and-mouth disease virus results in a rapid reduction of MHC class I surface expression.1998 · 68 citations
  3. 3A Single Amino Acid Substitution in Nonstructural Protein 3A Can Mediate Adaptation of Foot-and-Mouth Disease Virus to the Guinea Pig2001 · 126 citations
  4. 4A Protein Linkage Map of the P2 Nonstructural Proteins of Poliovirus1998 · 70 citations
  5. 5Interaction between the 5'-terminal cloverleaf and 3AB/3CDpro of poliovirus is essential for RNA replication1995 · 197 citations