April 9, 2009Journal of VirologyOpen Access

A Dominant-Negative Mutant of rab5 Inhibits Infection of Cells by Foot-and-Mouth Disease Virus: Implications for Virus Entry

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Population

IBRS-2 cells expressing alphavbeta8 as their FMDV receptor

Design

Preclinical

Authors

Discussion

Early endosomal FMDV entry via rab5 may guide antiviral design; leaves open in vivo efficacy and therapeutic translation.

Population

IBRS-2 cells expressing alphavbeta8 as their FMDV receptor

Intervention

Expression of dominant-negative (DN) mutants of cellular rab proteins (rab5, rab4, rab7, rab11)

Outcome

Number of FMDV-infected cellssurrogate

FMDV infection takes place predominantly from within early endosomes, requiring rab5 but not trafficking to late endosomal compartments.

Johns et al. (2009) studied this question.

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