Key result
Foot-and-mouth disease virus utilizes the clathrin-mediated endocytosis pathway to infect cultured cells, with viral replication initiated by acidification of endocytic vesicles.
Population
Cultured cells expressing alphaVbeta3 and alphaVbeta6 integrins infected with foot-and-mouth disease virus…
Design
Preclinical
Follow-up
up to 1 hour
Authors
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In vitro findings identify a potential FMDV entry target; leaves open in vivo relevance and therapeutic translation.
FMDV enters host cells via clathrin-mediated endocytosis and requires endosomal acidification for viral replication.
O’Donnell et al. (2005) studied Foot-and-mouth disease virus infection (in vitro). Foot-and-mouth disease virus (FMDV) infection vs. Uninfected cells or cells treated with endocytosis inhibitors was evaluated on Viral internalization pathway and colocalization with endocytic markers. Foot-and-mouth disease virus utilizes the clathrin-mediated endocytosis pathway to infect cultured cells, with viral replication initiated by acidification of endocytic vesicles.
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