Population
Vaccinia virus expression system for foot-and-mouth disease virus (FMDV) structural proteins
Comparison
Expression of P1-2A-3C cassette under T7… vs Mutant cassette with modified myristoylation…
Design
Preclinical
Authors
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Supports T7-vaccinia systems for FMDV capsid production; leaves open whether myristoylation blockade offers antiviral or vaccine strategies.
A vaccinia virus expression system utilizing the T7 promoter successfully synthesized and assembled foot-and-mouth disease virus empty capsids, which requires an intact myristoylation consensus sequence.
Abrams et al. (1995) studied this question.
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