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October 1, 1985Journal of VirologyOpen Access

Capsid intermediates assembled in a foot-and-mouth disease virus genome RNA-programmed cell-free translation system and in infected cells

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Population

Foot-and-mouth disease virus-infected cells and rabbit reticulocyte lysate programmed with foot-and-mouth…

Comparison

Cell-free translation system vs Infected cells (in vivo counterparts)

Design

Preclinical

Authors

MGMarvin J. GrubmanDMD.O. MorganJKJoe David Kendall

Discussion

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Overview

Cell-free systems may model early capsid assembly; leaves open whether neutralizing epitopes translate to vaccines or antivirals.

Structured PICO

P
Population
Foot-and-mouth disease virus-infected cells and rabbit reticulocyte lysate programmed with foot-and-mouth viral RNA
I
Intervention
Cell-free translation system
C
Comparator
Infected cells (in vivo counterparts)
O
Outcome
Capsid assembly, structural protein complex formation, and epitope presentationsurrogate

Capsid assembly in a cell-free system resembles viral morphogenesis in infected cells, with surface epitopes involved in cellular receptor interaction appearing early in virion morphogenesis.

Cite This Study

Grubman et al. (1985) studied this question.

synapsesocial.com/papers/6a20b46bf778797513eb8a1chttps://doi.org/10.1128/jvi.56.1.120-126.1985
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune and Antibody Responses to an Isolated Capsid Protein of Foot-and-Mouth Disease Virus1975 · 216 citations
  2. 2Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine1981 · 501 citations
  3. 3Demonstration of Neutralizing and Non-neutralizing Epitopes on the Trypsin-sensitive Site of Foot-and-Mouth Disease Virus1984 · 26 citations
  4. 4Four Independent Antigenic Determinants on the Capsid Polypeptides of Aphthovirus1983 · 19 citations
  5. 5Morphogenesis of Poliovirus II. Demonstration of a New Intermediate, the Proviron1973 · 81 citations