Population
Human and rodent models of pathological cardiac remodeling, including SH2B3 knockout mice, cardiac-specific…
Comparison
SH2B3 knockout or cardiac-specific SH2B3… vs Wild-type or control animals/cells
Design
Preclinical
Authors
Loading...
SH2B3 modulation merits exploration in pressure-overload models; hypothesis-generating and requires human validation before clinical consideration.
SH2B3 acts as a prohypertrophic modulator in cardiomyocytes, and its deficiency protects against pressure overload-induced cardiac remodeling and failure.
Zhu et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: