November 24, 1997Archives of Internal Medicine

Inability of the Activated Partial Thromboplastin Time to Predict Heparin Levels

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Why the study?

Does aPTT reliably predict heparin levels in patients receiving intravenous heparin for coronary artery disease or venous thromboembolism?

Population

65 patients

Design

Cohort

Authors

BBBrian BakerHuntington Museum of Art

Discussion

Member takes

Implication

aPTT poorly predicts heparin levels; leaves open whether anti-Xa monitoring improves safety in CAD or VTE.

Structured PICO

Does aPTT reliably predict heparin levels in patients receiving intravenous heparin for coronary artery disease or venous thromboembolism?

Population

65 patients (38 used to establish the therapeutic aPTT range, and 27 receiving intravenous heparin for coronary artery disease or venous thromboembolic disease)

Intervention

Activated partial thromboplastin time (aPTT) monitoring

Outcome

Correlation between aPTT and heparin (anti-factor Xa) levelssurrogate

The aPTT is not a reliable surrogate for predicting heparin levels, suggesting that direct measurement of heparin levels (anti-factor Xa) may be necessary for safe and effective monitoring.

Cite This Study

Brian Baker (1997) studied this question.

synapsesocial.com/papers/6a821bc40ebbaf848246bec0 https://doi.org/10.1001/archinte.1997.00440420107010

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Inability of the Activated Partial Thromboplastin Time to Predict Heparin Levels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inability of the Activated Partial Thromboplastin Time to Predict Heparin Levels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider