September 7, 2005Circulation

Deletion of Angiotensin II Type 2 Receptor Exaggerated Atherosclerosis in Apolipoprotein E–Null Mice

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Population

Apolipoprotein E-knockout mice and AT2 receptor/ApoE-double-knockout mice fed a high-cholesterol diet…

Comparison

Deletion of Angiotensin II type 2 receptor… vs ApoE-KO mice with intact AT2 receptors…

Design

Preclinical

Follow-up

10 weeks

Authors

MIMasaru IwaiKumamoto University RCRui ChenWenzhou Medical University ZLZhen LiCedars-Sinai Medical Center

Discussion

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Implication

Supports AT2-mediated attenuation of atherosclerosis in mice; leaves open translation to ARB therapy in patients.

Structured PICO

Population

Apolipoprotein E-knockout (ApoE-KO) mice and AT2 receptor/ApoE-double-knockout (AT2/ApoE-DKO) mice fed a high-cholesterol diet (1.25% cholesterol); cultured fetal vascular smooth muscle cells.

Intervention

Deletion of Angiotensin II type 2 (AT2) receptor; treatment with valsartan (AT1 receptor blocker) or PD123319 (AT2 receptor blocker).

Comparator

ApoE-KO mice with intact AT2 receptors; untreated controls.

Outcome

Atherosclerotic lesion formation in the aorta.surrogate

AT2 receptor stimulation attenuates atherosclerosis by inhibiting oxidative stress, suggesting the antiatherosclerotic effect of AT1 blockers like valsartan is partly mediated by unbound Ang II stimulating the AT2 receptor.

Cite This Study

Iwai et al. (2005) studied this question.

synapsesocial.com/papers/6a821bc6e282fcaf79c69eda https://doi.org/10.1161/circulationaha.104.525550

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Deletion of Angiotensin II Type 2 Receptor Exaggerated Atherosclerosis in Apolipoprotein E–Null Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Deletion of Angiotensin II Type 2 Receptor Exaggerated Atherosclerosis in Apolipoprotein E–Null Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider