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April 13, 2004Molecular and Cellular Biology

Acquired Expression of Periostin by Human Breast Cancers Promotes Tumor Angiogenesis through Up-Regulation of Vascular Endothelial Growth Factor Receptor 2 Expression

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Population

Human primary breast cancers, normal human breast tissues, tumor cell lines, and endothelial cells

Comparison

Overexpression of periostin vs Normal human breast tissues or control tumor…

Design

Preclinical

Authors

RSRong ShaoRenji HospitalSBShideng BaoCleveland ClinicXBXuefang BaiFudan University

Discussion

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Overview

Should not change oncology practice; hypothesis-generating for periostin-VEGFR2 targeting in tumor angiogenesis.

Structured PICO

P
Population
Human primary breast cancers, normal human breast tissues, tumor cell lines (xenografts in immunocompromised animals), and endothelial cells
I
Intervention
Overexpression of periostin
C
Comparator
Normal human breast tissues or control tumor cell lines
O
Outcome
Tumor progression and angiogenesis (up-regulation of vascular endothelial growth factor receptor Flk-1/KDR)surrogate

Periostin expression by human breast cancers promotes tumor angiogenesis by up-regulating VEGFR2 in endothelial cells, representing a novel mechanism in late-stage tumorigenesis.

Cite This Study

Shao et al. (2004) studied this question.

synapsesocial.com/papers/6a821cb7e6854618db7950bbhttps://doi.org/10.1128/mcb.24.9.3992-4003.2004
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Serum level of the periostin, a homologue of an insect cell adhesion molecule, as a prognostic marker in nonsmall cell lung carcinomas2001 · 109 citations
  2. 2Serial Analysis of Gene Expression1995 · 3,745 citations
  3. 3Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells2001 · 141 citations
  4. 4Targeting angiogenesis inhibits tumor infiltration and expression of the pro-invasive protein SPARC2000 · 74 citations