January 1, 2010Sunhwan'giOpen Access

Beneficial Effect of Efonidipine, an L- and T-Type Dual Calcium Channel Blocker, on Heart Rate and Blood Pressure in Patients With Mild-to-Moderate Essential Hypertension

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Why the study?

Does efonidipine reduce heart rate in patients with mild-to-moderate hypertension?

Population

53 patients with mild-to-moderate hypertension (sitting diastolic BP 90-110 mmHg)

Design

Cohort, open-labeled

Follow-up

12 weeks

Authors

Discussion

Efonidipine was associated with resting HR reduction in hypertension; hypothesis-generating for outcome trials.

Does efonidipine reduce heart rate in patients with mild-to-moderate hypertension?

Population

53 patients with mild-to-moderate hypertension (sitting diastolic BP 90-110 mmHg)

Intervention

Efonidipine 40 mg once daily for 12 weeks

Outcome

Change in heart rate (HR) from baseline to week 12surrogate

Efonidipine effectively lowers both heart rate and blood pressure in patients with mild-to-moderate hypertension.

Oh et al. (2010) studied this question.

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