January 1, 2003Circulation JournalOpen Access

Clinical Efficacy of Efonidipine Hydrochloride, a T-type Calcium Channel Inhibitor, on Sympathetic Activities. Examination Using Spectral Analysis of Heart Rate/Blood Pressure Variabilities and 123I-Metaiodobenzylguanidine Myocardial Scintigraphy.

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Why the study?

Does efonidipine hydrochloride reduce heart rate and sympathetic nervous activity in healthy subjects and patients with hypertension?

Population

Healthy subjects with resting heart rate ≥75 or <75 beats/min, untreated patients with essential…

Comparison

Efonidipine hydrochloride. vs Baseline or prior dihydropyridine L-type Ca…

Design

Cohort

Follow-up

Up to 4 weeks

Authors

KHKenji HaradaHeart Failure / Cardiomyopathy MNMasahiro NomuraThe University of Tokyo ANAkiyoshi NishikadoUji Hospital

Discussion

Member takes

Implication

Efonidipine was associated with favorable autonomic shifts and scintigraphy changes in high-HR patients; leaves open whether benefits alter outcomes in hypertension.

Structured PICO

Does efonidipine hydrochloride reduce heart rate and sympathetic nervous activity in healthy subjects and patients with hypertension?

Population

Healthy subjects with resting heart rate ≥75 or <75 beats/min, untreated patients with essential hypertension, and patients with high heart rate (≥75 beats/min) previously treated with a dihydropyridine L-type Ca channel inhibitor for 1 month or more.

Intervention

Efonidipine hydrochloride (administered as a single oral dose, a 4-week treatment, or switched from other dihydropyridine Ca antagonists).

Comparator

Baseline (pre-treatment) or prior dihydropyridine L-type Ca channel inhibitor therapy.

Outcome

Heart rate and autonomic nervous activity (evaluated via spectral analysis of heart rate/systolic blood pressure variability).surrogate

Efonidipine hydrochloride, a T-type calcium channel inhibitor, lowers heart rate and improves autonomic balance, offering potential cardioprotective benefits in hypertension.

Cite This Study

Harada et al. (2003) studied this question.

synapsesocial.com/papers/6a82442b2beaf6c72d877cfe https://doi.org/10.1253/circj.67.139

Topics

Hypertension management

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Implication

Efonidipine was associated with favorable autonomic shifts and scintigraphy changes in high-HR patients; leaves open whether benefits alter outcomes in hypertension.

Clinical Efficacy of Efonidipine Hydrochloride, a T-type Calcium Channel Inhibitor, on Sympathetic Activities. Examination Using Spectral Analysis of Heart Rate/Blood Pressure Variabilities and 123I-Metaiodobenzylguanidine Myocardial Scintigraphy.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Clinical Efficacy of Efonidipine Hydrochloride, a T-type Calcium Channel Inhibitor, on Sympathetic Activities. Examination Using Spectral Analysis of Heart Rate/Blood Pressure Variabilities and 123I-Metaiodobenzylguanidine Myocardial Scintigraphy.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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