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May refine elderly hypertension risk models; leaves open optimal drug regimens for outcomes.
Shammas E, Dickstein K . Drug selection for optimal treatment of hypertension in the elderly Drugs Aging 1997 11 : 19–26 Article CAS PubMed Google Scholar Rajkumar C . Hypertension in the elderly. In: Birkenhager WH, Reid JL, Bulpitt CJ (eds). Handbook of Hypertension , Vol 20, chapter 7 2000 pp 106–114 Hansson L et al . Effects of intensive blood-pressure lowering and low-dose aspirin inpatients with hypertension; principal results of the Hypertension Optimal Treatment (HOT) randomised trial Lancet 1998 351 : 1755–1762 Article CAS PubMed Google Scholar Beevers DG . Introduction: control of blood pressure by combination therapies J Hum Hypertens 1991 5 (Suppl 2) : 1–2 Google Scholar Ramsay LE et al . BHS Guidelines. Guidelines for management of hypertension: report of the third working party of the British Hypertension Society J Hum Hypertens 1999 13 : 569–592 Article CAS PubMed Google Scholar JNC VI . The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure Arch Int Med 1997 157 : 2413–2446 Article Google Scholar Fagan TC . Remembering the lessons of basic pharmacology Arch Int Med 1994 154 : 1430–1431 Article CAS Google Scholar Chalmers J . 1999 World Health Organization-International Society of Hypertension guidelines for the management of hypertension Clin Exper Hypertens 1999 21 : 1009–1060 Article CAS Google Scholar Kaplan NM . Low dose combinations in the treatment of hypertension: theory and practice J Hum Hypertens 1999 13 : 707–710 Article CAS PubMed Google Scholar Frishman WH et al . A multifactorial trial design to assess combination therapy in hypertension Arch Int Med 1994 154 : 1461–1468 Article CAS Google Scholar Chrysant SG . Antihypertensive effectiveness of low dose lisinopril-hydrochlorothiazide combination: a large multicenter study Arch Int Med 1994 154 : 737–743 Article CAS Google Scholar Goa KL, Wagstaff AJ . Losartan potassium. A review of its pharmacology, clinical efficacy and tolerability in the management of hypertension Drugs 1996 51 : 820–845 Article CAS PubMed Google Scholar Dahlof B et al . Improved antihypertensive efficacy of the felodipine-metoprolol extended-release tablet compared to each drug alone Blood Press 1993 2 (Suppl 1) : 37–45 Google Scholar MacGregor GA, Pevahouse JB, Cappucio FP, Markandu ND . Nifedipine sodium intake, diuretics and sodium balance Am J Nephrol 1987 7 (Suppl 1) : 44–48 Article Google Scholar Cappucio FP et al . A double-blind crossover study of the effect of concomitant diuretic therapy in hypertensivepatients treated with amlodipine Am J Hypertens 1991 4 : 297–302 Article Google Scholar Hansson L, Himmelmann A . Calcium antagonists in antihypertensive combination therapy J Cardiovasc Pharmacol 1991 18 (Suppl) : S76–S80 Article Google Scholar Bakris GL, Barnhill BW, Sadler R . Tratment of arterial hypertension in diabetic man: importance of therapeutic selection Kidney Int 1992 41 : 912–919 Article CAS PubMed Google Scholar MacGregor GA et al . Captopril in essential hypertension: contrasting effects of adding hydrochlorothiazide and propranolol Br Med J 1982 284 : 693–696 Article CAS Google Scholar Download references
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