January 1, 2002Journal of Lipid ResearchOpen Access

ApoA-I secretion from HepG2 cells: evidence for the secretion of both lipid-poor apoA-I and intracellularly assembled nascent HDL

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Population

HepG2 cells

Design

Preclinical

Follow-up

2 hours

Authors

JCJeffrey W. ChisholmNational Academies of Sciences, Engineering, and Medicine EBEllen R. BurlesonWake Forest University GSGregory S. ShelnessWake Forest University

Discussion

Member takes

Implication

Does not yet support HDL-targeted therapies; leaves open relevance of these pathways to human lipid metabolism.

Structured PICO

Population

HepG2 cells

Intervention

Radiolabeling with [(35)S]Met/Cys and pulse-chase experiments

Outcome

Lipidation state of apolipoprotein A-I (apoA-I) before and after secretionsurrogate

Demonstrates that apoA-I is secreted from HepG2 cells in both lipid-poor and intracellularly lipidated forms, providing insight into early HDL assembly.

Cite This Study

Chisholm et al. (2002) studied this question.

synapsesocial.com/papers/6a8242430ebbaf848246c2fc https://doi.org/10.1016/s0022-2275(20)30184-x

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Ask AI

Bookmark

ApoA-I secretion from HepG2 cells: evidence for the secretion of both lipid-poor apoA-I and intracellularly assembled nascent HDL

Discussion

Member takes

Implication

Structured PICO

Cite This Study

ApoA-I secretion from HepG2 cells: evidence for the secretion of both lipid-poor apoA-I and intracellularly assembled nascent HDL

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider