Why the study?
Does transplantation of Sca-1+/CD31- cells improve left ventricular remodeling in a mouse model of acute myocardial infarction?
Does transplantation of Sca-1+/CD31- cells improve left ventricular remodeling in a mouse model of acute myocardial infarction?
Transplantation of Sca-1+/CD31- cardiac progenitor cells attenuates adverse left ventricular remodeling and improves function post-myocardial infarction in mice, primarily through paracrine effects.
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Supports progenitor cell therapy exploration in post-MI models; leaves open human translation.
Wang et al. (2006) studied this question.
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