Why the study?
Does intramyocardial injection of Sca-1(+)CD31(-) cells with intact A2B receptor signaling improve cardiac recovery in mice with myocardial infarction?
Does intramyocardial injection of Sca-1(+)CD31(-) cells with intact A2B receptor signaling improve cardiac recovery in mice with myocardial infarction?
A2B receptor signaling in cardiac Sca-1(+)CD31(-) stromal cells is essential for their ability to improve cardiac recovery and vascularization after transplantation in myocardial infarction.
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A2B signaling enables stromal cell benefits in murine post-MI remodeling; hypothesis-generating for human cell therapy.
Ryzhov et al. (2013) studied this question.
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