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Serine and alanine have an inhibitory effect upon indole production from tryptophan by E8ch.coli.This effect is not a simple relation between the tryptophan and serine concentrations, and only holds when the enzyme is saturated with tryptophan.2. Fildes's (1945) finding that there is no evidence of tryptophan synthesis from indole and serine using cells of Esch. coli is confirmed.3. Using partition chromatographic analysis and retarding the reaction with mepacrine, alanine has been detected as an intermediate; under similar conditions the presence of serine has never been detected.
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A. Neuberger (1947) studied this question.
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