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A novel microcantilever biosensor was batch-fabricated with integrated circuit compatible micro-electro-mechanical system technology for joint detection of liver cancer biomarkers with high sensitivity, high throughput, high specification, and good precision. A micro-cavity was designed in the free end of the cantilever for local antibody-immobilization using micro-printing system, which can dramatically reduce the effect of adsorption-induced stiffness coefficientkvariation. A linear relationship between the resonance frequency shift and the antigen concentration was observed for three liver cancer biomarkers, alpha-fetoprotein,γ-glutamyl transpeptidase II, and hepatocyte growth factor. In addition, the presented immunosensing method has little cross reactivity to different antigens, paving the way to a highly specific technique. These approaches will promote clinical application of the cantilever sensors in early cancer diagnosis.
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Wang et al. (2016) studied this question.
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