November 1, 1988Diabetes
Metabolic Effects of Low-Dose Insulin Therapy on Glucose Metabolism in Diabetic Ketoacidosis
Why the study?
Does low-dose insulin therapy improve hepatic glucose production and tissue glucose disposal in patients with diabetic ketoacidosis?
Population
5 insulin-dependent diabetes mellitus (IDDM) subjects admitted with diabetic ketoacidosis (DKA)
Comparison
Low-dose insulin treatment followed by a 2-h… vs Healthy controls and nonketotic IDDM subjects
Follow-up
6 hours
Authors
Discussion
Loading...
Member takes
Implication
Reinforces low-dose insulin use in DKA; extends mechanistic data but remains hypothesis-generating pending randomized confirmation.
Structured PICO
Does low-dose insulin therapy improve hepatic glucose production and tissue glucose disposal in patients with diabetic ketoacidosis?
P
Population
5 insulin-dependent diabetes mellitus (IDDM) subjects admitted with diabetic ketoacidosis (DKA)
I
Intervention
Low-dose insulin treatment (5–10 U/h, 1 mU·kg−1·min−1) followed by a 2-h insulin-clamp
C
Comparator
Healthy controls and nonketotic IDDM subjects (for baseline comparisons)
O
Outcome
Hepatic glucose production (HGP) and peripheral glucose disposalsurrogate
In diabetic ketoacidosis, low-dose insulin therapy lowers plasma glucose primarily by inhibiting hepatic glucose production rather than stimulating peripheral glucose uptake.
Cite This Study
Luzi et al. (1988) studied this question.