Why the study?
Does low-dose insulin treatment reveal marked insulin resistance in diabetic subjects in ketoacidosis compared to normal hyperglycemic volunteers?
Population
15 diabetic subjects admitted in ketoacidosis and 6 normal volunteers rendered hyperglycemic by a combined…
Comparison
"Low-dose" (6-10 U/h) insulin treatment vs Normal volunteers rendered hyperglycemic by…
Design
Cohort
Authors
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Reveals marked insulin resistance in DKA during low-dose insulin; hypothesis-generating and should not yet alter practice.
Does low-dose insulin treatment reveal marked insulin resistance in diabetic subjects in ketoacidosis compared to normal hyperglycemic volunteers?
Diabetic patients in ketoacidosis exhibit marked insulin resistance, with significantly reduced glucose clearance compared to normal subjects during low-dose insulin therapy.
Barrett et al. (1982) studied this question.
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