Answers are grounded in this paper and cite their sources.
The development of a transmissible spongiform encephalopathy upon uptake of the infectious agent in feed was studied in the model system scrapie in hamsters. Compared to single dosing, repeated dosing caused disease at a considerable higher incidence. The risk of infection was higher when the time interval between repetitive dosing was short. There was a statistically significant trend of clearance of infectivity with time.
No takes yet. Share an insight, caveat, or question.
Diringer et al. (1998) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: