Why the study?
Does doxorubicin exposure alter the amino acid profile in cardiac muscle tissue?
Population
In vitro cardiac muscle tissue (myocardium)
Comparison
Doxorubicin exposure vs Heart tissue before application of doxorubicin
Design
Preclinical
Authors
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May indicate doxorubicin cardiotoxicity mechanism in animals; leaves open human relevance and requires prospective validation.
Does doxorubicin exposure alter the amino acid profile in cardiac muscle tissue?
Doxorubicin directly reduces the quantitative composition of major amino acids in the myocardium, which may represent a mechanism contributing to its cardiotoxic effects.
Heger et al. (2013) studied this question.
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