Why the study?
Does oesophageal acid infusion alter autonomic function in patients with non-cardiac chest pain?
Population
28 patients with non-cardiac chest pain, mean age 40.5 years, 13 females, and 10 matched healthy controls.
Comparison
Oesophageal acidification (0.1 N HCl infusion) vs Baseline and matched healthy controls
Design
Case-control
Authors
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Suggests autonomic differences in acid-sensitive non-cardiac chest pain; hypothesis-generating for mechanisms and requires prospective validation before clinical use.
Does oesophageal acid infusion alter autonomic function in patients with non-cardiac chest pain?
Patients with non-cardiac chest pain who experience angina-like symptoms during esophageal acid exposure have decreased resting vagal activity that paradoxically increases during acid infusion.
Gervais Tougas (2001) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: