High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases

Figures

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  Figure 1. Single regression analysis among serum UA, plasma BNP and LVEF Scatter plots and a simple regression line (orange straight line) with the regression equation demonstrate the correlation between two values among UA, plasma BNP, and LVEF. BNP, B-type natriuretic peptide; LVEF, left ventricular ejection fraction; UA, uric acid.

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  Figure 2. Single regression analysis among serum UA, plasma BNP, LVEF and other risk factors Scatter plots and a simple regression line (orange straight line) with the regression equation demonstrate the correlation between two values among UA, plasma BNP, LVEF, gender, age, BMI, and creatinine. The means of each value are marked in blue (male) or red (female) plots in each panel, with standard deviations (same colored lines). Statistical significance was indicated as the P value with the horizontal bar in the upper part of each scatter plot in the top three panels. BNP, B-type natriuretic peptide; LVEF, left ventricular ejection fraction; UA, uric acid.

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  Figure 3. Path models from A-1 to D-4 were dependent on the gender difference, ageing, BMI, and creatinine (the groups quartered by each value) The path has a coefficient showing the standardized coefficient of a regressing independent variable on a dependent variable of the relevant path (UA to Log BNP; UA to LVEF; LVEF to Log BNP). These variables are standardized regression coefficients (direct effect) with P values if statistical significance was present, squared multiple correlations [on the upper right side of rectangles (in italics)] and correlations among exogenous variables. The positive regression coefficients are indicated as blue-colored values, and the negative regression coefficients are indicated as red-colored values. Uncolored values denote P values less than 0.05. BNP, B-type natriuretic peptide; LVEF, left ventricular ejection fraction; UA, uric acid; e, extraneous variable.

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  Figure 4. Single regression analysis between UA and LVEF and between UA and Log BNP among obese, adolescent males, and among lean, aged females These upper and lower panels demonstrate a single regression analysis between UA and LVEF, and UA and Log BNP among each group, divided into obese, adolescent males (upper panels: age <67 years and BMI ≥ 24.2 kg/m2) and lean, aged females (lower panels: age ≥67 years and BMI < 24.2 kg/m2). Scatter plots and a simple regression line (orange straight line) with the regression equation demonstrate the correlation between the two values among UA, plasma BNP, and LVEF. BNP, B-type natriuretic peptide; LVEF, left ventricular ejection fraction; UA, uric acid.