Key result
Uric acid concentrations ≥8.7 mg/dL, rather than NT-proBNP ≥3800 pg/mL, were associated with significantly decreased event-free survival in patients with nonischemic dilated cardiomyopathy.
Why the study?
Does uric acid level provide greater prognostic information than NT-proBNP in patients with advanced heart failure with nonischemic dilated cardiomyopathy?
Population
122 patients with advanced heart failure with nonischemic dilated cardiomyopathy (DCM)
Comparison
Uric acid (UA) level measurement vs N-terminal pro B-type natriuretic peptide level…
Design
Cohort
Authors
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May support uric acid over NT-proBNP for prognostication in nonischemic dilated cardiomyopathy; leaves open prospective validation before practice change.
Cohort (n=122)
Does uric acid level provide greater prognostic information than NT-proBNP in patients with advanced heart failure with nonischemic dilated cardiomyopathy?
Uric acid levels ≥8.7 mg/dL are an independent predictor of adverse clinical events and may offer greater prognostic value than NT-proBNP in advanced nonischemic dilated cardiomyopathy.
Kim et al. (2010) conducted a cohort in advanced heart failure with nonischemic dilated cardiomyopathy (n=122). Uric acid (UA) level vs. N-terminal pro B-type natriuretic peptide (NT-proBNP) level was evaluated on composite of cardiac death and readmission for heart failure. Uric acid concentrations ≥8.7 mg/dL, rather than NT-proBNP ≥3800 pg/mL, were associated with significantly decreased event-free survival in patients with nonischemic dilated cardiomyopathy.
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