Evaluation of Antiproliferative and Antileishmanial Activities of R-(+)- limonene-derived 2-Amino-5-aryl-1,3,4-thiadiazoles

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Natural products are great prototypes for the development of new compounds with pharmacologic properties. In this work, the monoterpene R-(+)limonene was used to obtain a series of 1,3,4-thiadiazoles and their antitumor and antileishmania activities against Leishmania amazonenses were investigated. The analogous 4-methyl (4b) was potentially active against melanoma tumor cells (UACC-62), while the derivative 4-methoxy (4c) and 4-dimethylamino (4d) were the most active against L. amazonensis.