Why the study?
Human herpesviruses-6 and -7 establish lifelong latency or persistence, and host immune cells rely on cell-surface proteins to identify and target infected cells.
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Population
T cells infected with human herpesvirus-6A
Design
In vitro experimental study
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Human herpesviruses-6 and -7 infect essentially 100% of the world's population before the age of 5 and then remain latent or persistent in their host throughout life. As such, these viruses are among the most pervasive and stealthy of all viruses. Host immune cells rely on the presence of surface-expressed proteins to identify and target virus-infected cells. Here, we investigated the changes that occur to proteins expressed on the cell surface of T cells after infection with human herpesvirus-6A. We discovered that HHV-6A infection results in a reduction of CD45 on the surface of infected T cells and impaired activation in response to T cell receptor stimulation.
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Whyte et al. (2021) studied this question.
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