Atrial Functional Tricuspid Regurgitation

BACKGROUND: Despite increasing clinical recognition of atrial functional tricuspid regurgitation (AF-TR), there remains limited literature regarding the characteristics, outcomes, and adverse prognosticators for this valve lesion. OBJECTIVES: This study aimed to elucidate clinical and echocardiographic characteristics and outcomes and to develop a novel risk model in a large cohort of patients with significant AF-TR. METHODS: Consecutive patients with at least moderate-to-severe AF-TR seen between January 2004 and December 2018 were retrospectively studied. Univariable and multivariable logistic regression (OR) were conducted to determine the risk factors and develop novel risk scores for 1-year all-cause mortality. RESULTS: . Multivariable analyses identified right heart failure (OR: 2.40; 95% CI: 1.31-4.41), lower serum albumin (OR: 0.88; 95% CI: 0.85-0.92), higher right atrial volume indexed (OR: 1.25; 95% CI: 1.04-1.49), lower tricuspid annular plane systolic excursion/right ventricular systolic pressure ratio (OR: 0.82; 95% CI: 0.70-0.95), and higher TR-effective regurgitant orifice area (OR: 1.11; 95% CI: 1.02-1.21) to be independently associated with 1-year mortality, from which a risk model was derived with good discrimination (area under the curve: 0.87). CONCLUSIONS: , validating the guidelines threshold for severe tricuspid regurgitation. A novel risk score for 1-year mortality in patients with AF-TR was developed, offering potential utility for risk stratification and treatment guidance; however, external validation is needed.