Why the study?
Is train-of-four (TOF) monitoring a reliable indicator of neuromuscular blockade in critically ill ICU patients?
Is train-of-four (TOF) monitoring a reliable indicator of neuromuscular blockade in critically ill ICU patients?
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The authors caution that train-of-four monitoring may not be a reliable indicator of neuromuscular blockade in critically ill ICU patients.
A pattern of nerve stimulation called train‐of‐four (TOF) is frequently used to monitor therapy with nondepolarizing neuromuscular blocking agents in patients treated in intensive care units. Based on our experience with TOF monitoring in several critically ill patients, we believe its application as an indicator of neuromuscular blockade may be problematic in this setting.
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Tschida et al. (1995) studied this question.
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