Key result
Atracurium and tubocurarine produced significantly greater train-of-four fade during the onset of neuromuscular block compared to vecuronium or pancuronium.
Why the study?
Does the type of nondepolarising neuromuscular blocking agent affect train-of-four fade during onset of block?
Population
Subjects receiving nondepolarising neuromuscular blocking agents
Comparison
Atracurium, vecuronium, pancuronium or… vs Comparison among the different neuromuscular…
Design
Other
Authors
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May warrant agent-specific TOF interpretation during NMBA onset; hypothesis-generating and should not yet change practice.
Does the type of nondepolarising neuromuscular blocking agent affect train-of-four fade during onset of block?
Different nondepolarising neuromuscular blocking agents exhibit varying degrees of train-of-four fade during the onset of block, with vecuronium showing the least fade.
Gibson et al. (1989) studied Neuromuscular block. Nondepolarising neuromuscular blocking agents vs. Between-drug comparison was evaluated on Fade in the train-of-four (TOF) responses. Atracurium and tubocurarine produced significantly greater train-of-four fade during the onset of neuromuscular block compared to vecuronium or pancuronium.
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