September 1, 1971Archives of Internal Medicine

Saline suppression of plasma aldosterone in hypertension

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Why the study?

Does intravenous saline infusion during recumbency differentiate primary aldosteronism from essential hypertension based on plasma aldosterone suppression?

Structured PICO

Does intravenous saline infusion during recumbency differentiate primary aldosteronism from essential hypertension based on plasma aldosterone suppression?

Population

38 subjects including 9 normal subjects, 18 patients with essential hypertension, 6 with aldosteronism (adrenal adenomas or glucocorticoid suppressible hyperplasia), 1 with hypokalemic hypertension and low plasma renin activity, and 4 with renovascular stenosis and hypertension.

Intervention

Intravenous infusion of 2 liters of isotonic saline during four hours of recumbency

Outcome

Plasma aldosterone concentration after infusionsurrogate

The saline infusion recumbency test is a rapid method to evaluate plasma aldosterone suppression and identify primary aldosteronism.

Discussion

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Implication

Supports saline suppression testing for aldosteronism differentiation; leaves open prospective validation before changing practice.

Cite This Study

D. C. Kem (1971) studied this question.

synapsesocial.com/papers/6a8253ae820a57e9dc878694 https://doi.org/10.1001/archinte.128.3.380

View Full Paper

Ask AI

Bookmark

Saline suppression of plasma aldosterone in hypertension

Structured PICO

Discussion

Implication

Cite This Study

Saline suppression of plasma aldosterone in hypertension

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider