November 1, 1987Journal of VirologyOpen Access

Expression of hepatitis A virus cDNA in Escherichia coli: antigenic VP1 recombinant protein

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Population

Escherichia coli expressing hepatitis A virus (HAV) cDNA clones coding for the capsid protein VP1

Design

Preclinical

Authors

Discussion

Supports recombinant HAV VP1 antigen production in E. coli; hypothesis-generating for diagnostics or vaccines pending higher-model validation.

Population

Escherichia coli expressing hepatitis A virus (HAV) cDNA clones coding for the capsid protein VP1

Intervention

Cloning into expression vector pUR290 and expression in Escherichia coli

Outcome

Reaction of recombinant fusion protein in immunoblot with rabbit anti-HAV serum

Demonstrates the successful expression of antigenic hepatitis A virus VP1 recombinant protein in Escherichia coli.

Ostermayr et al. (1987) studied this question.

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Supports recombinant HAV VP1 antigen production in E. coli; hypothesis-generating for diagnostics or vaccines pending higher-model validation.