Population
Escherichia coli expressing recombinant hepatitis A virus 3C proteinase
Design
Preclinical
Authors
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Supports HAV 3C inhibitor screening; leaves open clinical translation pending in vivo validation.
The study successfully expressed, purified, and characterized the hepatitis A virus 3C proteinase, identifying cysteine 172 as its active site nucleophile.
Malcolm et al. (1992) studied this question.
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