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November 1, 1992Journal of VirologyOpen Access

Intermolecular cleavage of hepatitis A virus (HAV) precursor protein P1-P2 by recombinant HAV proteinase 3C

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Population

In vitro-translated and radiolabeled hepatitis A virus precursor protein P1-P2 and recombinant HAV…

Design

Preclinical

Authors

YKYuri KusovUniversity of LübeckWSWolfgang SommergruberFH Campus WienMSMichael SchreiberBernhard Nocht Institute for Tropical Medicine

Discussion

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Implication

Animal findings on HAV 3C specificity warrant no clinical change; leaves open mechanistic parallels with cardioviruses for future study.

Structured PICO

P
Population
In vitro-translated and radiolabeled hepatitis A virus (HAV) precursor protein P1-P2 and recombinant HAV proteinase 3C expressed in bacteria
I
Intervention
Incubation of HAV precursor protein P1-P2 with extracts of bacteria transformed with plasmids containing recombinant HAV 3C
O
Outcome
Intermolecular cleavage activity (identification of cleavage products P1, VP1, and VPO-VP3)surrogate

Recombinant HAV proteinase 3C demonstrates intermolecular cleavage activity on the HAV precursor protein P1-P2, similar to cardiovirus 3C.

Cite This Study

Kusov et al. (1992) studied this question.

synapsesocial.com/papers/6a6fcb4aac440176ef287475https://doi.org/10.1128/jvi.66.11.6794-6796.1992
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphogenesis of hepatitis A virus: isolation and characterization of subviral particles1990 · 91 citations
  2. 2Poliovirus Protein 3CD Is the Active Protease for Processing of the Precursor Protein P1 in vitro1988 · 188 citations
  3. 3Protease required for processing picornaviral coat protein resides in the viral replicase gene1979 · 142 citations
  4. 4Expression and characterization of recombinant hepatitis A virus 3C proteinase1992 · 61 citations
  5. 5Identification of precursors of structural proteins VP1 and VP2 of hepatitis A virus1992 · 14 citations