October 1, 1998Journal of VirologyOpen Access

Processing of Proteinase Precursors and Their Effect on Hepatitis A Virus Particle Formation

View Full Paper

Ask AI

Bookmark

Population

Eukaryotic cells expressing Hepatitis A virus (HAV) proteinase precursors

Comparison

Transient expression of a nested set of… vs Different precursor constructs compared to each…

Design

Preclinical

Authors

CPChristian ProbstFundação Carlos Chagas MJMonika JechtUniversity of Lübeck VGVerena Gauss‐MüllerUniversity of Lübeck

Discussion

Member takes

Implication

Hypothesis-generating for HAV capsid assembly; leaves open therapeutic targeting of P3 domain in humans.

Structured PICO

Population

Eukaryotic cells expressing Hepatitis A virus (HAV) proteinase precursors

Intervention

Transient expression of a nested set of 3Cpro-containing proteins (P3, 3ABC, 3BCD, 3CD, 3BC, and 3C) and coexpression with P1-2A

Comparator

Different precursor constructs compared to each other

Outcome

Extent of processing (cleavage products) and viral particle formationsurrogate

Efficient liberation of structural proteins from P1-2A is necessary but not sufficient for productive HAV capsid formation, suggesting polypeptides flanking 3Cpro promote viral particle assembly.

Cite This Study

Probst et al. (1998) studied this question.

synapsesocial.com/papers/69d56f7375589c71d767d8a7 https://doi.org/10.1128/jvi.72.10.8013-8020.1998

View Full Paper

Ask AI

Bookmark

Processing of Proteinase Precursors and Their Effect on Hepatitis A Virus Particle Formation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Processing of Proteinase Precursors and Their Effect on Hepatitis A Virus Particle Formation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider