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August 1, 1999Journal of VirologyOpen Access

Maturation of the Hepatitis A Virus Capsid Protein VP1 Is Not Dependent on Processing by the 3C pro Proteinase

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Population

Hepatitis A virus polyprotein processing models

Comparison

Site-directed mutagenesis of potential VP1/2A… vs Wild-type HAV / unmutated cleavage sites

Design

Preclinical

Authors

AMAnnette MartinCentre National de la Recherche ScientifiqueDBDanièle BénichouCentre National de la Recherche ScientifiqueSCShih-Fong ChaoUniversity of North Carolina at Chapel Hill

Discussion

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Implication

HAV VP1 maturation proceeds independently of 3Cpro; leaves open cellular protease identity and antiviral targeting in animal models.

Structured PICO

P
Population
Hepatitis A virus (HAV) polyprotein processing models (heterologous expression system based on recombinant vaccinia viruses and infectious molecular clone of HAV)
I
Intervention
Site-directed mutagenesis of potential VP1/2A cleavage sites (e.g., Glu764-Ser765, Arg764 substitution)
C
Comparator
Wild-type HAV / unmutated cleavage sites
O
Outcome
VP1 maturation and viral infectivity

Maturation of the HAV VP1 capsid protein is not dependent on 3Cpro processing and may be uniquely dependent on a cellular proteinase.

Cite This Study

Martin et al. (1999) studied this question.

synapsesocial.com/papers/6a891d94c9c00c271ba2aabbhttps://doi.org/10.1128/jvi.73.8.6220-6227.1999
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proteinase 3C-mediated processing of VP1-2A of two hepatitis A virus strains: in vivo evidence for cleavage at amino acid position 273/274 of VP11997 · 19 citations
  2. 2Morphogenesis of hepatitis A virus: isolation and characterization of subviral particles1990 · 91 citations
  3. 3Synthesis and assembly of hepatitis A virus-specific proteins in BS-C-1 cells1993 · 41 citations
  4. 4Antigenic and genetic variation in cytopathic hepatitis A virus variants arising during persistent infection: evidence for genetic recombination1991 · 210 citations
  5. 5Molecular cloning and partial sequencing of hepatitis A viral cDNA1985 · 75 citations