Why the study?
Does atorvastatin or antagomir-208a reduce myocardial fibrosis and endoglin expression in a rat model of volume overload heart failure?
Does atorvastatin or antagomir-208a reduce myocardial fibrosis and endoglin expression in a rat model of volume overload heart failure?
Mir-208a increases endoglin expression to induce myocardial fibrosis in volume overloaded heart failure, and atorvastatin can attenuate this fibrosis by inhibiting endoglin expression.
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Hypothesis-generating in rat volume-overload model; human trials needed before considering antagomir-208a or atorvastatin for fibrosis.
Wang et al. (2014) studied this question.
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