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Highlights the role of peptide bond cleavage and proteolysis in the formation of proteins such as insulin and poliovirus proteins.
Cleavage of peptide bonds plays an important role in the formation of certain proteins. The classic case is zymogen activation, but the more recent finding that the 2-chain molecule of insulin is formed by removal of a large segment from the center of a single polypeptide (Chance, Ellis, and Bromer, 1968) suggests that proteolysis may have a more widespread role in protein formation than had previously been imagined.
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Baltimore et al. (1969) studied this question.
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