Why the study?
African swine fever virus poses a major threat to the global swine industry, but little is known about its cell entry mechanisms due to its multilayered structure and large genome.
This review highlights the complex, multilayered cell entry mechanisms of ASFV, emphasizing the need for further molecular virology research to develop innovative combat strategies.
Complex ASFV entry may inform targeted antivirals; leaves open cell-specific mechanisms for validation.
African swine fever virus (ASFV) is a highly complex virus that poses a significant threat to the global swine industry. However, little is known about the mechanisms of ASFV cell entry because ASFV has a multilayered structure and a genome encoding over 150 proteins. This review aims to elucidate the current knowledge on cell entry mechanisms of ASFV and the cellular and viral proteins involved. Experimental evidence suggests that ASFV utilises multiple pathways for entry, which may be cell or tissue type dependent, but the intricate nature of ASFV has hindered the identification of cellular and viral proteins involved in this process. Therefore, further research into the molecular virology of ASFV is essential to advance our understanding of the ASFV entry mechanisms, which will pave the way for innovative strategies to combat this formidable pathogen.
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Netherton et al. (2024) studied this question.
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