Key result
African swine fever virus enters host macrophages via macropinocytosis and clathrin-mediated endocytosis, followed by low pH-driven disassembly and inner envelope fusion.
Highlights the structural complexity and entry pathways of the African swine fever virus into host macrophages.
African swine fever virus (ASFV) is a large, multienveloped DNA virus composed of a genome-containing core successively wrapped by an inner lipid envelope, an icosahedral protein capsid, and an outer lipid envelope. In keeping with this structural complexity, recent studies have revealed an intricate entry program. This Gem highlights how ASFV uses two alternative pathways, macropinocytosis and clathrin-mediated endocytosis, to enter into the host macrophage and how the endocytosed particles undergo a stepwise, low pH-driven disassembly leading to inner envelope fusion and core delivery in the cytoplasm.
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Germán Andrés (2017) conducted a review in African swine fever virus infection. African swine fever virus enters host macrophages via macropinocytosis and clathrin-mediated endocytosis, followed by low pH-driven disassembly and inner envelope fusion.
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