Key result
African swine fever virus becomes engulfed by a two-membraned collapsed cisterna derived from the endoplasmic reticulum during cytoplasmic maturation.
Population
African swine fever virus (ASFV)-infected cells
Design
Preclinical
Authors
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ASFV envelopment mechanism clarified by EM; leaves open whether precursor membranes represent antiviral targets.
This study demonstrates that African swine fever virus acquires its inner envelope from a two-membraned collapsed cisterna derived from the endoplasmic reticulum.
Andrés et al. (1998) studied African swine fever virus (ASFV) infection. ASFV recombinant inducibly expressing major capsid protein p72 vs. Absence of inducer was evaluated on Viral morphogenesis and membrane origin. African swine fever virus becomes engulfed by a two-membraned collapsed cisterna derived from the endoplasmic reticulum during cytoplasmic maturation.
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