Key result
The ASFV transmembrane protein pEP84R is essential for viral core assembly and genome packaging by targeting core shell polyproteins to the inner viral envelope.
Why the study?
Details of African swine fever virus outer capsid assembly are relatively well understood, but the mechanisms of core formation remain unclear.
The pEP84R protein is crucial for ASFV core assembly and genome packaging, identifying it as a potential therapeutic target.
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Positions pEP84R as candidate ASFV antiviral target; leaves open validation and therapeutic translation.
Alejo et al. (2023) studied African swine fever virus (ASFV) infection. Repression of pEP84R expression (vEP84Ri without IPTG) vs. Permissive pEP84R expression (+IPTG) or wild-type ASFV was evaluated on Formation of infectious virus particles and core assembly. The ASFV transmembrane protein pEP84R is essential for viral core assembly and genome packaging by targeting core shell polyproteins to the inner viral envelope.
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