Key result
Repression of the African swine fever virus structural protein p54 arrested virus morphogenesis prior to the formation of precursor membranes, indicating it is essential for envelope precursor recruitment.
The transmembrane structural protein p54 is essential for the recruitment and transformation of ER membranes into precursors of the African swine fever virus envelope.
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p54 may be a target for ASFV control; leaves open translation to vaccines or therapies in swine.
Rodrı́guez et al. (2004) studied African Swine Fever Virus infection. Repression of p54 synthesis vs. Permissive conditions (IPTG) was evaluated on Virus morphogenesis. Repression of the African swine fever virus structural protein p54 arrested virus morphogenesis prior to the formation of precursor membranes, indicating it is essential for envelope precursor recruitment.
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