August 6, 2025Journal of VirologyOpen Access

ASFV pE146L-induced ER remodeling is essential for viral replication

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pE146L is identified as essential for the replication of african swine fever virus (ASFV), contributing to viral factory formation.
The absence of pE146L disrupts endoplasmic reticulum (ER) aggregation and viral replication across multiple experimental settings.
The study presents the first high-resolution crystal structure of pE146L, revealing its lipid-binding capabilities critical for ASFV morphogenesis.
The findings illuminate the significance of intermolecular disulfide bonds for ER aggregation, proposing new pathways for antiviral drug development.

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Research demonstrates that pE146L is crucial for viral replication in African swine fever virus, suggesting implications for antiviral strategies.

Guo et al. (2025) studied this question.

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Research demonstrates that pE146L is crucial for viral replication in African swine fever virus, suggesting implications for antiviral strategies.