Key result
The African swine fever virus inner membrane protein pE199L is required for virus entry by enabling membrane fusion and core penetration into the host cell.
Why the study?
Effective vaccines or antivirals for African swine fever virus are lacking, and relevant gaps remain in understanding the fundamental biology of its infection cycle.
The identification of pE199L as essential for ASFV membrane fusion and core penetration provides a potential target for future antiviral strategies.
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pE199L offers an antiviral target in ASFV; animal data leave open translation to disease control.
Matamoros et al. (2020) studied African swine fever virus infection. pE199L protein was evaluated on Virus entry and membrane fusion. The African swine fever virus inner membrane protein pE199L is required for virus entry by enabling membrane fusion and core penetration into the host cell.
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