October 30, 2015Stroke
Incidence of Stroke or Systemic Embolism in Paroxysmal Versus Sustained Atrial Fibrillation
Why the study?
Is paroxysmal atrial fibrillation associated with a lower risk of stroke or systemic embolism compared to sustained atrial fibrillation in Japanese patients?
Population
3,304 Japanese patients with atrial fibrillation from a community-based survey in Fushimi-ku, Kyoto, Japan.
Comparison
Paroxysmal atrial fibrillation (PAF) vs Sustained atrial fibrillation
Design
Cohort
Authors
Discussion
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Member takes
Implication
PAF was associated with lower stroke/SE risk than sustained AF regardless of OAC; hypothesis-generating in Japanese cohorts and requires prospective confirmation before practice change.
Structured PICO
Is paroxysmal atrial fibrillation associated with a lower risk of stroke or systemic embolism compared to sustained atrial fibrillation in Japanese patients?
P
Population
3,304 Japanese patients with atrial fibrillation (1,588 with paroxysmal AF, 1,716 with sustained AF) from a community-based survey in Fushimi-ku, Kyoto, Japan.
I
Intervention
Paroxysmal atrial fibrillation (PAF)
C
Comparator
Sustained (persistent or permanent) atrial fibrillation
O
Outcome
Incidence of stroke or systemic embolismhard clinical
In a Japanese community-based cohort, paroxysmal AF was associated with a significantly lower risk of stroke or systemic embolism compared to sustained AF, regardless of oral anticoagulant use.
Cite This Study
Takabayashi et al. (2015) studied this question.