December 8, 2021Science AdvancesOpen Access

Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

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Why the study?

Does UCP1 prevent vascular inflammation and atherosclerosis in animal models?

Population

Mice and UCP1 knockin pigs

Comparison

UCP1 deficiency vs controls, and UCP1 knockin pigs

Design

Preclinical animal study

Authors

PGPing GuNanjing General Hospital of Nanjing Military Command XHXiaoyan HuiHKU-Pasteur Research Pole QZQiantao ZhengUniversity of Michigan

Discussion

Member takes

Implication

UCP1 may protect against obesity-related endothelial dysfunction in models; hypothesis-generating for IL-1β therapies in humans.

Structured PICO

Does UCP1 prevent vascular inflammation and atherosclerosis in animal models?

Population

Mice with dietary obesity-induced endothelial dysfunction and UCP1 knockin pigs

Intervention

UCP1 deficiency (mice), UCP1 knockin (pigs), IL-1β neutralization, or chemical mitochondrial uncoupler

Comparator

Wild-type or control animals

Outcome

Endothelial dysfunction, vascular inflammation, and atherogenesissurrogate

UCP1 acts as a protective gatekeeper against vascular inflammation and atherosclerosis by blocking NLRP3 inflammasome-dependent IL-1β production.

Cite This Study

Gu et al. (2021) studied this question.

synapsesocial.com/papers/6a825b26cedf96c170877fac https://doi.org/10.1126/sciadv.abl4024

View Full Paper

Ask AI

Bookmark

Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome–dependent interleukin-1β production

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider